The mice became the first animals to return safely to Earth after a space journey, pointing to a potential solution for preventing bone density loss in astronauts during extended microgravity missions.

Astronauts go through loss of bone gravity, during the low gravity missions

A quick bone loss can be life threatening

, and this has been a major factor that space agencies are supposed to address before humans can be sent to Mars.

Bone loss and kidney stones are well known as essential problems for astronauts to overcome during extended stays in space. Crew members engage in physical exercise for two and a half hours a day, six times a week (fifteen hours a week) while in orbit to avoid these issues

While on station, the ISS crew monitored the mice, measuring their bone density, observing changes in muscle mass, and administering the inhibitor agent. While in space, the wild-type mice lost significant bone and muscle mass, which corresponds to what we know about microgravity and the human

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