In a new study, it has been found how inconvenient is death as an event for a living brain. A cascade of effects has been observed as oxygen starts depleting and translating the DNA in its last efforts to save the life

The scientists have compared the post-mortem brain tissue and samples collected from living patients in which significant differences were revealed for the first time in the way the RNA strands are modified.

The researchers from the Icahn School of Medicine at Mount Sinai in New York emphasised the way specific base codes of adenosine (A) are swapped with very different bases, which is inosine (I) in messenger RNA.

“Until now, the investigation of A-to-I editing and its biological significance in the mammalian brain has been restricted to the analysis of postmortem tissues,” genomicist Michael Breen said while speaking to Science Alert.

What does the human brain do after death?

And now new research suggests the brain is incredibly active as a person dies. Researchers have seen highly organized gamma waves in the brain in the last moments of life. These waves are linked to higher brain functions such as memory, cognition, and attention.

What is the wave of death in neuroscience?

Researchers studying the brain’s final moments have gained new insight into the “wave of death” that occurs before a brain’s activity fully flatlines. When neural activity stops, it doesn’t stop abruptly, but over time. The team hopes to find ways to keep the brain functioning even when the heart and lungs 

How does death affect the brain?

“The emotional trauma of grief results in profound changes to brain function due to the repetitive stress of the fight or flight response and neuroplasticity, which is the remodeling of the brain in response to experience and changes in our environment,” said Shulman, “Over time, these mechanisms result in a …8

What is the scientific study of death?

thanatology, the description or study of death and dying and the psychological mechanisms of dealing with them. Thanatology is concerned with the notion of death as popularly perceived and especially with the reactions of the dying, from whom it is felt much can be learned about dealing with death’s approach

What is the new science of death?

As more and more people were resuscitated, scientists learned that, even in its acute final stages, death is not a point, but a process. After cardiac arrest, blood and oxygen stop circulating through the body, cells begin to break down, and normal electrical activity in the brain gets disrupted

Human minds have always been curious about life after death, what’s there on the other side. For years, we have been working to find answers to these questions, but haven’t been really able to crack the code. However, scientists now have reached half way through as they have found that a human brain keeps working long after dying even when the heart stops.

For centuries, scientists and researchers have believed that dying is not the end of brain activity. This is the first time that it has been proven right now

Human brain remains alive long after heart stop working

This study was a follow up of a previous investigation into near-death experiences. The study aimed to explore the experiences of patients who underwent cardiopulmonary resuscitation (CPR) in hospitals across the US and UK. 

A pilot sub-study involved monitoring electroencephalogram (EEG) activity and cerebral oxygen levels during CPR offering a glimpse into the diminishing consciousness of those on the brink of dying.

By using fresh samples from living individuals, we were able to uncover significant differences in RNA editing activity that previous studies, relying only on postmortem samples, may have overlooked,” he added.

For changing the genes – which were encoded by double-stranded helixes of DNA – to functional proteins, their sequences need to be copied into different formats based instead on RNA. 

Other RNA structures, which have amino acid building blocks, can translate these ‘messengers’ into proteins.

This intermediary transcription and translation service has been part of billions of years of evolution and has added a whole new library of proteins.

Understanding these differences helps improve our knowledge of brain function and disease through the lens of RNA editing modifications, which can potentially lead to better diagnostic and therapeutic approaches,” he added.

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